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Nancy Schimelpfening
Depression Blog

By Nancy Schimelpfening, About.com Guide to Depression

Are Generic Drugs the Same?

Thursday September 11, 2003
CKOLLARS1 asks: "After taking Remeron for several years I was pleased recently to find a generic was available (especially since I self-pay and the generic is considerably cheaper). Surprisingly though the generic doesn't 'feel the same.' On the generic I've noticed having depressive thoughts similar to when I missed my daily dose of real Remeron in the past. Am I just imagining a difference? Has anyone else had a similar experience?"
Comments
September 14, 2006 at 9:56 pm
(1) John Barker says:

I use the generic brand of Remeron and it has worked fine. check out the URL above on generic drugs or go to MedicineNet.com to see the articile on generics. Good luck. And I hope for you continued good mental health.

John

October 11, 2006 at 2:35 am
(2) Tom says:

I have noticed a big difference between branded and generic versions of mirtazapine. I even have a packet of each at 2 different locations (as I move between residence). For the generic version I suffer from quite sever night tremors where as the normal I don’t. I always ask for the branded type now.

November 28, 2006 at 10:56 pm
(3) shelia says:

I HAVE RECENTLY STARTED ON THE GENERIC REMERON, FEEL AS IF I NEED MORE THAN 15 MG.HAS ANYONE HAD PROBLEMS WITH FEET SWELLING? MY DAUGHTER HAS BEEN HELPED SO MUCH [W/REMERON 30 MG] I KNOW IT CAN HELP ME.

January 12, 2007 at 6:17 am
(4) Doug says:

4 years ago I was given a sample of brand-name Remeron. When it seemed to help with my Paxil withdrawal, my doctor gave me a prescription for the generic – which was like taking nothing at all!As for leg swelling – yes! It seems to go hand-in-hand with my blood tests showing hight liver function tests (LFTs). Basically, they gave me more drugs than my liver could handle. If you or your daughter have leg/ankle/feet swelling, make sure you tell your doctor and ask if your LFTs are normal. It’s one of the most basic simple blood tests they can do. I would also caution you that just because it helped someone else (even a close relative) does not mean that it will be the right medicine for you.

February 9, 2007 at 4:30 pm
(5) Glenn says:

I take remeron chiefly to combat my early awakening sleep pattern. I found that the generic leaves the system much faster– if I missed a dose of the Brand name, I still slept through the night. If I miss one dose of the generic, I’m buzzing awake at 3:30 AM.

May 30, 2007 at 9:08 am
(6) mario ribeiro says:

I tried generic and i felt very badly excited, could’nt sleep. There had been a big differenca beetewen Remeron Soltab 15mg and the 30 mg generic. Now i’ve just started remeron 30mg soltab, and its beteer than the generic.

July 6, 2007 at 3:01 pm
(7) kristine says:

Hi,i have been on remeron for years,on 30mgs,now since my drug coverage changed,i can only get generic,i don’t feel like it is quite the same,i have alot of depressive thoughts,i was wondering if this is normal?How can i gwet the name brand again,i calledr a few pharmacies,and they only have generics now,what should i do,since i have severe anxiety and depressive mood swings,along with panic,i feel as if i am doomed,plus i take clonazepam,mirtazapine as i have said,and tegretol,and seroquel only as needed,would like to hear from you if you have some suggestions.Sincerely Kristine

January 5, 2008 at 6:02 am
(8) John Van Leeuwen says:

Hi. Im currently on mirtazapine for which helped me INSTANTLY quit marijuana, as i was heavily addicted. It puts me to sleep very well. but i have noticed some differences from the branded compared to generic. I feel depressed and like im in a rutt on the generic, i only had branded for 1 repeat but im going to try branded next time to compare. I am not working and im in a difficult relationship and living with the person as i have no where else, so this could be possible reason, but yes i agree the generic is somewhat different from the branded. Hope this helps. John

February 4, 2008 at 2:55 pm
(9) Andy says:

I have DEFINETLY noticed a differernce with the brand name vs. the generic for remeron. Brand name at 30 mg. vs. generic at 30 mg. is like night and day. I found that generic at 45 mg. is better and resembles the brand name at 30 mg. but still not as good. The difference is so big that I’m willing to pay $150+ now for a month supply of brand name vs. $5 for a month supply of generic.

February 20, 2008 at 6:51 pm
(10) Edgar says:

Some generics work different or are weaker. Try changing generic brands (if you can) and test them. I’ve found it’s only one laboratory that makes a bad generic version while the other ones are relatively similar.

October 4, 2008 at 6:19 am
(11) Rob says:

To Kristine below whose coverage now only provides for the generic and who is experiencing a number of side effects, I recommend you speak immediately to your primary doctor and ask if they can make a case for making an exception for you due to medical necessity. Perhaps your health plan will make an exception and cover the name-brand for you.

November 14, 2008 at 8:31 am
(12) eoin says:

have been taking generic for almost a year (30mg by night) now, over the last 4 to 5 months my anxiety has gone through the roof, i have the worst waking nightmares, have had mild seizures(only in the last month), dizziness and at times feel like i am tripping if i feel uncomfortable and am in a neon lighted setting, am meeting my doc in 3 days to get this sorted out as i currently am scared to leave the house at this stage and cant go to work properly

April 8, 2009 at 6:20 am
(13) Marisol says:

to eoin,
i have been taking remeron now for almost a week and i’m on the 15mg at night and i have had terible nightmares already! this is exactly what i was looking for! i wanted to see if that was happening to anyone else or if it were just me. i have sickle cell and was diagnosed with major depressive disorder just last thursday (when i started taking it) so along with my normal medications that i take for the sickle cell, i now am taking remeron. not only for depression, but insomnia as well. at least the remeron has knocked off the 2 meds i take normally from the list, (lexapro *didn’t do a THING for me* and ambien CR)and i’m also 22, so the normal depressive tendencies i have have kind of kicked up a bit more. i just wanna stick around with it longer to see if there’ll be any changes later.
good luck everyone!

April 24, 2009 at 11:51 pm
(14) lulu says:

I have been taking mirtazapine (generic) for about 10 days. I am currently on 7.5 mg. I’ve been having weird nightmares and feel quite irritable. I am probably going to switch to brand name pretty soon, seeing my doctor in a few days.

April 29, 2009 at 8:35 am
(15) Cat says:

Thanks for leaving all your comments. I was given Mirtazapine (for Remeron) because of having Kaiser Permanente, and it is cheaper for them to give me that on my insurance than to give me the actual brand name. I have been told in the past, that generics “are the same” all the time. I am on several prescribed drugs for pain, and nerve & muscle damage from a serious car accident in 2001. Therefore, I don’t think I should be on this drug due to possible liver damage, it makes me sleep far too long, and I’m still depressed.

October 28, 2009 at 3:46 pm
(16) julie says:

I am taking Remeron brand name. it is worth every penney.The pharmacy changed me to generic for a year. I Went down hill real fast. my psychiatrist told me generic antideppresants are not the same.so [i pay out of pocket for brand name remeron,I feel great!

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