Forum: Abrupt Loss of Wellbutrin Effectiveness
Tuesday January 6, 2004
"Wellbutrin back in October gave me a tremendous boost in just a few days (after weaning off a very uncomfortable trial of Zoloft). I felt so happy, unworried, unobsessed, powerful and social, it was the greatest feeling in my life. I felt what I thought might be "normal" or I could easily be positive about most everything. It sustained for almost 6 weeks and then bam it seemed to lose effectiveness. Got permission from p-doc to double the dose to 300 mg for the time being (next visit in 2 weeks), but not much difference. I've felt the cloud of depression coming on strong for the last few weeks. It's not the worst it's been but it's back and I just can't seem to shake it and kickstart myself back into that state of mind no matter what CBT thought technique I try. Could it be that I'm just so disappointed that the elated state of Wellbutrin wore off that I fell back into the depressive thought pattern that I've lived with for so long?"


I’ve been taking Wellbutrin for about a week now… and I’m starting to feel that feeling you were describing. My plan is to remain positive. I think what you need to do, is realize that a medicine is supposed to make you better, but sustain you forever. Like with any drug, after a while you want more and more, or you turn all crazy. I suffer from depression, but I DO want to get better, remain positive, despite your urge to feel sad about life. re-arange your house, walk with your head held high, look everyone you come across in the eye, don’t let your emotions have power over you. Only you can make yourself better, Wellbutrin just helps get those neurotransmitters jumping. My advice is wean yourself off the drug, until you can go days without it, then begin the process again… but this time with a better attitude. Not that the drug will cure you, but that it will help you to cure yourself. I really hope this helps… I want it to help me, so I’ll give it a try with you.
~Jimmie Baker (like you)
I’m sorry… *NOT sustain you forever
I’m the only one in this world. Can please someone join me in this life? Or maybe death…
Thanks a a lot