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By Nancy Schimelpfening, About.com Guide to Depression since 1998

FAQ: How Long Does It Take Zoloft to Wear Off?

Monday April 5, 2004
Zoloft has a half-life of about one day. That means that for every day that passes without taking the medication the level in the blood falls by 50%. After one day the level is reduced to 50% of the original level, after two days to 25%, after three days to 12.5%, and so on. Read More

Comments

November 20, 2008 at 1:19 am
(1) Miss My Orgasm says:

I have been taking Zoloft for about 2.5 months now and I feel great. The exception is I have never had a problem having an orgasm before the medication. I truly enjoy sex with my partner, I want him all the time however I cannot have an orgasm. It is very frustrating and I am considering discontinuing the use of anitdepressants. Is there any other alternative for women besides stopping the Zoloft? Please help! :(

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