Have you been through numerous drug trials without getting relief from your depression? Do antidepressants only work for a short while before "pooping out"? Treatment-resistant depression (TRD) can be very discouraging for those who have it, but there are options that may be able to help you.
One option is electroconvulsive therapy (ECT). While ECT doesn't come without side-effects, it does bring rapid relief for about 80 percent of patients and it can work where other treatments have failed.
A newer option is vagus nerve stimulation (VNS), which involves the implantation of a pacemaker-like device to periodically send a pulse to the vagus nerve, which communicates with brain cells involved in mood control.
If medications have failed you, please don't give up hope. Speak with your doctor about other treatment options available to you, such as ECT and VNS.