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Abilify (Aripiprazole)

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Updated September 30, 2011

Written or reviewed by a board-certified physician. See About.com's Medical Review Board.

Indications and Usage:

Abilify (aripiprazole) is an atypical antipsychotic used in the treatment of schizophrenia, bipolar disorder, and as an add-on treatment for major depressive disorder. It may be used for acute treatment of mania or mixed episodes of bipolar I disorder, either by itself or in combination with valproate. It may also be used in the acute treatment of agitation associated with either schizophrenia or bipolar I disorder.

How Abilify Is Prescribed:

Abilify is available in swallow tablet form (2, 5, 10, 15, 20 and 30 mg), orally disintegrating tablets (10 and 15 mg), oral solution (1 mg/mL) and injection (9.75 mg/1.3 mL single dose vial).

The tablet and oral solution forms are prescribed to be taken once daily. It is not necessary to time dosing according to meals. If given by injection, it is advised that you wait at least two hours between doses. Follow your prescription instructions.

Warnings and Precautions for Abilify:

Adverse Reactions While Using Abilify:

The most common adverse reactions in adult patients in clinical trials were nausea, vomiting, constipation, headache, dizziness, akathisia, anxiety, insomnia, and restlessness.

The most common adverse reactions in the pediatric clinical trials were sleepiness, headache, vomiting, extrapyramidal side effects, fatigue, increased appetite, insomnia, nausea, colds and weight gain.

Drug Interactions:

Always notify your doctor about any medications you will be taking with Abilify.

Drugs that interact with Abilify include:

  • Strong CYP3A4 (for example, ketoconazole) or CYP2D6 (for example, fluoxetine) inhibitors will increase Abilify's concentration in the blood. The dose should be decreased if used in conjunction with these types of drugs, so be sure to tell your doctor if you are on them.
  • CYP3A4 inducers (for example, carbamazepine) will decrease Abilify's concentration. With these drugs, your doctor will likely increase your dose.

Source:

U.S. Full Prescribing Information, Including Boxed Warnings. Bristol Myers Squibb. Accessed: Dec. 21, 2009.

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