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Should I Take Zoloft?

Zoloft (Sertraline)


Updated September 20, 2011

Written or reviewed by a board-certified physician. See About.com's Medical Review Board.

What Is Zoloft? | Dosage | Side Effects | Interactions | Warnings and Precautions | Should I Take Zoloft? | Stopping Zoloft

There are certain groups of people who either should not take Zoloft or should exercise caution if they do take it. If you meet any of the conditions below, you should inform your doctor.

Who Should Not Take Zoloft

Your doctor will not prescribe Zoloft for you if you take any of the following drugs:

Use of the oral concentrate of Zoloft with Antabuse is also not advised.

Zoloft is not appropriate for you if you have a known hypersensitivity to sertraline or any of the inactive ingredients in it.

Who Should Take Zoloft With Caution

  • Patients with liver impairment: The effects of Zoloft on patients with moderate or severe liver disease have not been studied. If your doctor prescribes you the drug, it will be in a lower or less frequent dose than others receive.

  • Pregnant women in the third trimester: Babies exposed to Zoloft during the third trimester may develop complications following birth, including prolonged hospitalization, the need for breathing support, and tube feeding. The risks of continuing Zoloft should be weighed against the benefits and consideration given to tapering off the drug. If you are pregnant or considering becoming pregnant while using Zoloft, please seek advice from your doctor.

  • Patients with bipolar disorder: Zoloft should be used with caution in the treatment of bipolar disorder as it can potentially contribute to mania or worsening mood cycling.


Medication Guide. Pfizer, Inc. Accessed: Jan. 27, 2010. http://www.zoloft.com

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