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Zoloft Interactions

Zoloft (Sertraline)


Updated September 20, 2011

Written or reviewed by a board-certified physician. See About.com's Medical Review Board.

What Is Zoloft? | Dosage | Side Effects | Interactions | Warnings and Precautions | Should I Take Zoloft? | Stopping Zoloft

It's important to be aware of possible Zoloft interactions. Always inform your doctor of any prescription or over-the-counter medications you are taking, including any herbs or supplements.

Drugs that may affect or be affected by Zoloft include, but are not limited to:

  • Warfarin (Coumadin)
  • Cimetidine (Tagamet)
  • Triptans
  • Diazepam (Valium)
  • Atenolol (Tenormin)
  • Aspirin
  • Lithium
  • Pimozide (Orap)
  • Phenytoin (Dilantin)
  • Valproate (Depakote)
  • Terfenadine (Seldane)
  • Carbamazepine (Tegretol)
  • Cisapride (Propulsid)
  • Propafenone (Rythmol)
  • Flecainide (Tambocor)
  • Linezolid (Zyvox)
  • Tramadol (Ultram)
  • Tolbutamide (Orinase)
  • St. John's wort
  • Tryptophan
  • Other antidepressants


Medication Guide. Pfizer, Inc. Accessed: Jan. 27, 2010. http://www.zoloft.com

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