21. "Here Comes The Rain Again" - EurythmicsIn The Dave Stewart Songbook, Stewart explained: "I'd been out on 46th Street and bought an early Casio keyboard, about 20 inches long with very small keys. It was an overcast day. Annie (Lennox) was sitting in my room, and I was playing some little riff on the keyboard sitting on the window ledge, and I was playing these little melancholy A minor-ish chords with the B note in it. I kept on playing this riff, and Annie was looking out the window at the slate grey sky above the New York skyline and just sang spontaneously, 'Here Comes The Rain Again.' And that was all we needed. you see, like with a lot of our songs, you only need to start with that one line, and that one atmosphere, that one note, or that intro melody. And the rest of it was like a puzzle where we needed to just fill in the missing pieces."
22. "I Don't Feel Very Receptive Today" - UnderOathThe lead singer, Spencer Chamberlain, has been rumored to have talked about his depression and difficult childhood at concerts and this song is said to be about his experiences with depression.
23. "I Don't Know" - Ozzy Osbourne
Here, Ozzy sings about his depression and uncertainty about the future after getting kicked out of his band, Black Sabbath
24. "I Wish It Would Rain" - The TemptationsThe lyrics to this song where written by Motown staff writer Roger Penzabene after learning that his wife was cheating on him.
25. "I'll Find Me" - Steve Azar and Tony ColtonCo-writer Tony Colton was reportedly inspired by the death of his wife to cancer when he penned this song.
26. "Iceland" - Mary Chapin CarpenterThis song reflects a dark period in Carpenter's life when she become ill with blood clots in her lungs and couldn't go on tour. She was very depressed because she felt she had let everyone down.
27. "If It Makes You Happy" - Sheryl CrowAccording to Crow, she felt a great of pressure for her sophomore album to match the success of its predecessor. These feelings inspired this song.
28. "Industrial Disease" - Dire StraitsThis song deals with the strikes, depression and dysfunction associated with the decline of the British manufacturing industry in the eighties.
29. "Irvine" - Kelly ClarksonClarkson wrote this song in the bathroom of her dressing room while performing at the Irvine Wireless Ampitheatre and feeling overwhelmed. She says: "I had reached my lowest point. I thought: 'I don't want to smile or talk about myself, or do a photo shoot. I don't want to do anything.' Four or five years straight of doing this stuff caught up on me. Everyone wanted to keep it going and I couldn't. Even though I love my job, I couldn't do it all the time."
30. "King Of Pain" - The PoliceSting wrote this song during a period when he had separated from his first wife and was not getting along with the other members of the band.