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Tricyclic Antidepressant

By Nancy Schimelpfening, About.com

Updated September 22, 2007

About.com Health's Disease and Condition content is reviewed by the Medical Review Board

Definition: Tricyclic antidepressants are older antidepressants which inhibit reuptake of serotonin and norepinephrine. In addition, they interfere with the metabolism of other compounds in the central nervous system, the amines.
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