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Zoloft Side Effects

Zoloft (Sertraline)


Updated July 03, 2014

Written or reviewed by a board-certified physician. See About.com's Medical Review Board.

What Is Zoloft? | Dosage | Side Effects | Interactions | Warnings and Precautions | Should I Take Zoloft? | Stopping Zoloft

As with all medications, Zoloft may cause certain side effects.

The most common side effects experienced with Zoloft include:

For many, side effects may be minimal or lessen with time, but if you experience any side effects that do not go away or become disruptive to your life, please consult with your doctor for advice.

In some cases, side effects may be severe and possibly life-threatening. If you experience any of the following more serious side effects, please seek immediate medical assistance:

  • severe allergic reaction (rash; hives; itching; difficulty breathing; tightness in the chest; or swelling around the mouth, face or lips)
  • unusual behavior
  • black or bloody stools
  • chest pain
  • decreased bladder control
  • decreased concentration
  • decreased coordination
  • exaggerated reflexes
  • fainting
  • new or worsening agitation
  • panic attacks
  • fast or irregular heartbeat
  • fever
  • hallucination
  • memory loss
  • aggressiveness
  • impulsiveness
  • irritability
  • hostility
  • exaggerated feeling of well-being
  • restlessness, or the inability to sit still
  • persistent or severe ringing in the ears
  • persistent, painful erection
  • red, swollen, blistered, or peeling skin
  • seizures
  • severe or persistent anxiety or trouble sleeping
  • severe or persistent headache
  • stomach pain
  • suicidal thoughts or attempts
  • tremor
  • unusual bruising or bleeding
  • unusual or severe mental or mood changes
  • unusual weakness
  • vision changes
  • worsening of depression

Not all potential side effects are listed here. Please ask your doctor or pharmacist if you require further information.

If you wish to report side effects to the FDA, they may be reached at 1-800-FDA-1088.


Medication Guide. Pfizer, Inc. Accessed: Jan. 27, 2011. http://www.zoloft.com

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